Actin hitches a ride to the cleavage furrow
نویسندگان
چکیده
منابع مشابه
Vesicles and actin are targeted to the cleavage furrow via furrow microtubules and the central spindle
During cytokinesis, cleavage furrow invagination requires an actomyosin-based contractile ring and addition of new membrane. Little is known about how this actin and membrane traffic to the cleavage furrow. We address this through live analysis of fluorescently tagged vesicles in postcellularized Drosophila melanogaster embryos. We find that during cytokinesis, F-actin and membrane are targeted...
متن کاملCleavage furrow positioning
To complete the cell cycle, the cleavage furrow draws the plasma membrane toward the cell center, pinching the cytoplasm into two lobes that are subsequently separated into two cells. The position of the cleavage furrow is induced by the mitotic spindle during early anaphase. Although the mechanism of cleavage furrow positioning is not understood at a molecular level, recent results suggest tha...
متن کاملCleavage Furrow Formation in a Telolecithal Egg
Formation of the first cleavage furrow in the telolecithal egg of Loligo was studied with the electron microscope . Before the actual furrow forms, a dense filamentous band develops below the plasma membrane from membrane-bounded dense bodies which appear to be Golgi-derived . The egg surface is thrown into a number of longitudinal folds which parallel the furrow and eventually become incorpora...
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The mitotic spindle determines the cleavage furrow site during metazoan cell division, but whether other mechanisms exist remains unknown. Here we identify a spindle-independent mechanism for cleavage furrow positioning in Drosophila neuroblasts. We show that early and late furrow proteins (Pavarotti, Anillin, and Myosin) are localized to the neuroblast basal cortex at anaphase onset by a Pins ...
متن کاملCentrosomes: CNN's Broadcast Reaches the Cleavage Furrow
Centrosomin (CNN), a core Drosophila centrosome protein, interacts with the newly identified protein Centrocortin to promote cleavage furrow formation in the early embryo. Significantly, this activity is distinct from CNN's well-established role in centrosome-based microtubule organization.
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2008
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1815iti4